Anaerobic regulation of Shigella flexneri virulence: ArcA regulates Fur and iron acquisition genes.

@article{Boulette2007AnaerobicRO,
  title={Anaerobic regulation of Shigella flexneri virulence: ArcA regulates Fur and iron acquisition genes.},
  author={Megan L. Boulette and Shelley M. Payne},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 19},
  pages={
          6957-67
        }
}
Invasion and plaque formation in epithelial monolayers are routinely used to assess the virulence of Shigella flexneri, a causative agent of dysentery. A modified plaque assay was developed to identify factors contributing to the virulence of S. flexneri under the anaerobic conditions present in the colon. This assay demonstrated the importance of the ferrous iron transport system Feo, as well as the global transcription factors Fur, ArcA, and Fnr, for Shigella plaque formation in anoxic… CONTINUE READING
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