Anaerobic obligatory xylitol production in Escherichia coli strains devoid of native fermentation pathways.

@article{Akinterinwa2011AnaerobicOX,
  title={Anaerobic obligatory xylitol production in Escherichia coli strains devoid of native fermentation pathways.},
  author={Olubolaji Akinterinwa and Patrick C Cirino},
  journal={Applied and environmental microbiology},
  year={2011},
  volume={77 2},
  pages={
          706-9
        }
}
Anaerobic glucose oxidation was coupled to xylose reduction in a nonfermentative Escherichia coli strain expressing NADPH-dependent xylose reductase. Xylitol production serves as the primary means of NAD(P)(+) regeneration, as glucose is converted primarily to acetate and CO(2). The membrane-bound transhydrogenase PntAB is required to achieve the maximum theoretical yield of four moles of xylitol per mole of glucose consumed. 

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