Anaerobic neutrophil-dependent killing of Actinobacillus actinomycetemcomitans in relation to the bacterial leukotoxicity.

@article{Johansson2000AnaerobicNK,
  title={Anaerobic neutrophil-dependent killing of Actinobacillus actinomycetemcomitans in relation to the bacterial leukotoxicity.},
  author={Anders Johansson and Gunnar Sandstr{\"o}m and Rolf L K Claesson and Lennart H{\"a}nstr{\"o}m and Sotirios Kalfas},
  journal={European journal of oral sciences},
  year={2000},
  volume={108 2},
  pages={136-46}
}
The effect of leukotoxin on the interaction of Actinobacillus actinomycetemcomitans with human polymorphonuclear leukocytes (PMNL) was studied under anaerobic conditions with strains able to produce high or low amounts of leukotoxin. PMNL morphology, phagocytosis and killing were examined by transmission electron microscopy and bioassays, respectively. At ratios of > or =25 bacteria/PMNL, a highly toxic A. actinomycetemcomitans strain completely destroyed the PMNL within 7 min, resulting in… CONTINUE READING
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