Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549

@inproceedings{Yasutake2013AnacardicAA,
  title={Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549},
  author={Tetsuo Yasutake and Hiroo Wada and Manabu Higaki and Masuo Nakamura and Kojiro Honda and Masato Watanabe and Haruyuki Ishii and Shigeru Kamiya and Hajime Takizawa and Hajime Goto and Shu Hashimoto and Bruce K. Rubin},
  booktitle={F1000Research},
  year={2013}
}
OBJECTIVE AND DESIGN The histone acetylation processes, which are believed to play a critical role in the regulation of many inflammatory genes, are reversible and regulated by histone acetyltransferases (HATs), which promote acetylation, and histone deacetylases (HDACs), which promote deacetylation. We studied the effects of lipopolysaccharide (LPS) on histone acetylation and its role in the regulation of interleukin (IL)-8 expression.  MATERIAL A human alveolar epithelial cell line A549 was… CONTINUE READING
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