Anabolic steroids in sport: biochemical, clinical and analytical perspectives

@article{Kicman2003AnabolicSI,
  title={Anabolic steroids in sport: biochemical, clinical and analytical perspectives},
  author={Andrew T. Kicman and D. B. Gower},
  journal={Annals of Clinical Biochemistry},
  year={2003},
  volume={40},
  pages={321 - 356}
}
International Olympic Committee accredited laboratories play a key role in upholding the principle of fair play and innate ability, as desired by the majority of sports competitors and spectators. Not only does doping damage the image of sport, but it can also be harmful to the individual. The great majority of samples test negative but, when an adverse finding is declared, the analytical data must be of a sufficiently high standard to withstand legal challenges by third parties. The most… Expand
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References

SHOWING 1-10 OF 236 REFERENCES
Anabolic steroids: Metabolism, doping and detection in equestrian and human sports
TLDR
During the 1960s, many pharmaceutically licensed chemical analogues of testosterone were released on to the market, these analogues being designed to enhance the anabolic effect for clinical purposes but competitors also desired these drugs, wanting the muscle building effects of testosterone but without the androgenic effects. Expand
Anabolic steroids: the gremlins of sport.
  • T. Todd
  • Medicine
  • Journal of sport history
  • 1987
TLDR
An attempt to provide a chronology and an insight into this baleful aspect of modern sport of athletes using anabolic steroids. Expand
Doping in sport: misuse, analytical tests, and legal aspects.
TLDR
The proceedings of this symposium, published in this issue of Clinical Chemistry, bring together health, social, endocrine, and analytical perspectives in a widely read peer-reviewed journal. Expand
Anabolic steroids: A review of the literature
TLDR
A detailed review of the literature on anabolic steroids is provided that provides the reader the information needed to make an informed decision on the relative risks and benefits of anabolic steroid to the athlete. Expand
Anabolic steroid abuse
TLDR
Education alone is probably not the answer to stopping anabolic steroid abuse but is an essential first step in combating this problem, physicians should avoid condemning individuals who choose to use anabolic steroids and encourage discussion of use with their health providers. Expand
Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government.
Several classified documents saved after the collapse of the German Democratic Republic (GDR) in 1990 describe the promotion by the government of the use of drugs, notably androgenic steroids, inExpand
Recent Developments in the Toxicology of Anabolic Steroids
TLDR
The anabolic steroids are toxic drugs with both long and short term effects, and their abuse by athletes is to be decried, particularly in view of the frequent and prolonged use by the young. Expand
Issues in detecting abuse of xenobiotic anabolic steroids and testosterone by analysis of athletes' urine.
TLDR
Among ancillary tests to help discriminate between naturally increased T/E values and those reflecting T use, the most promising is determination of the carbon isotope ratio. Expand
Anabolic steroids: A review of their effects on the muscles, of their possible mechanisms of action and of their use in athletics
  • F. Cellotti, P. Cesi
  • Chemistry
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 1992
Anabolic steroids are synthetic molecules developed in the hope of obtaining a complete separation of the androgenic and myotrophic (anabolic) actions of testosterone. Such a goal has never beenExpand
Nandrolone excretion is not increased by exhaustive exercise in trained athletes.
TLDR
This study provides compelling evidence that endogenous nandrolone production in male athletes, during two very different types of exercise, produces urine levels far below the IOC threshold of 2 ng.mL(-1) urine, and thus exercise does not induce endogenous n androlone secretion. Expand
...
1
2
3
4
5
...