Anabolic effects of intermittent PTH on osteoblasts.

  title={Anabolic effects of intermittent PTH on osteoblasts.},
  author={Edward M. Greenfield},
  journal={Current molecular pharmacology},
  volume={5 2},
Intermittent parathyroid hormone (iPTH) is the only FDA-approved therapy for bone loss due to conditions such as osteoporosis that increases bone formation by osteoblasts; all other therapies approved for osteoporosis block bone resorption by osteoclasts. The anabolic effects of iPTH are likely due to a combination of multiple mechanisms, including induction of immediate-early genes, increased expression and/or activity of essential osteoblast transcription factors, and downregulation of anti… CONTINUE READING
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