Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.

@article{Reeve1980AnabolicEO,
  title={Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.},
  author={J. Reeve and P. Meunier and J. Parsons and M. Bernat and O. Bijvoet and P. Courpron and C. Edouard and L. Klenerman and R. Neer and J. Renier and D. Slovik and F. Vismans and J. Potts},
  journal={British Medical Journal},
  year={1980},
  volume={280},
  pages={1340 - 1344}
}
After baseline studies, 21 patients with osteoporosis were treated with human parathyroid hormone fragment (PTH 1-34) given as once-daily subcutaneous injections for 6-24 months. The dose used did not cause hypercalcaemia even in the first few hours after injection. Calcium and phosphate balances improved in some patients, but there was no significant improvement in the group values. There were, however, substantial increases in iliac trabecular bone volume: the mean increase, confirmed by… Expand
Effects of two treatment regimes with synthetic human parathyroid hormone fragment on bone formation and the tissue balance of trabecular bone in greyhounds.
TLDR
The adult greyhound was found to be similar to adult man with respect to kinetic and histomorphometric indices of calcium metabolism and it is possible that the increased osteoblastic activity induced by the daily injection regime in trabecular bone is dependent on the noncontinuous nature of the PTH stimulus. Expand
Human parathyroid peptide treatment of vertebral osteoporosis
TLDR
It is concluded that in combination with oestrogens, hPTH peptides given daily injections hold great promise for the treatment of patients with osteoporosis who have already lost substantial amounts of spinal cancellous bone. Expand
Effects of Daily Treatment with Parathyroid Hormone on Bone Microarchitecture and Turnover in Patients with Osteoporosis: A Paired Biopsy Study *
  • D. Dempster, F. Cosman, +8 authors R. Lindsay
  • Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2001
TLDR
It is indicated that daily PTH treatment exerts anabolic action on cortical bone in patients with osteoporosis and also can improve cancellous bone microarchitecture. Expand
Short-term effects of synthetic human parathyroid hormone-(1--34) administration on bone mineral metabolism in osteoporotic patients.
TLDR
It is indicated that low doses of parathyroid hormone may promote bone formation, whereas higher doses clearly have an adverse effect on the skeleton. Expand
Periodic courses of human 1–34 parathyroid peptide alternating with calcitriol paradoxically reduce bone remodelling in spinal osteoporosis
TLDR
This type of treatment regime, with its calcitonin‐like effect, might be effective in reducing net bone loss due to imbalance between bone formation and resorption at the BMU level, particularly in patients with increased numbers of BMUs (‘high turnover’ osteoporosis). Expand
Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone.
TLDR
Results indicate that trabecular bone mass did not increase at the expense of cortical bone, and the bone response with changes in serum calcium or phosphate did not differ significantly from control serum calcium, serum phosphate, or serum phosphate. Expand
Anabolic Effects of Human Biosynthetic Parathyroid Hormone Fragment (1–34), LY333334, on Remodeling and Mechanical Properties of Cortical Bone in Rabbits
TLDR
The combination of the effects of biosynthetic human PTH and Haversian remodeling resulted in an enhancement of the ultimate stress, stiffness, and work to failure of the femur of rabbits given the higher dose of PTH. Expand
The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate--is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system?
TLDR
The model of old sheep, which closely resembles the situation in old human, shows that the anabolic effect of PTH on bone is not maintained when PTH is coadministered with a bisphosphonate, in marked contrast to results noted in the growing rat. Expand
Treatment of postmenopausal osteoporosis with daily parathyroid hormone plus calcitriol
An ideal treatment for osteoporosis would increase bone strength by increasing the amount of mineralized lamellar bone, the thickness of cortical bone, and the connectivity of trabecutar bone, andExpand
Calcium-47 kinetic measurements of bone turnover compared to bone histomorphometry in osteoporosis: the influence of human parathyroid fragment (hPTH 1-34) therapy.
TLDR
Nineteen patients with involutional osteoporosis have been studied by means of combined 47 Ca kinetic and calcium balance studies and morphometric analysis of iliac crest bone biopsies taken after double tetracycline labelling, finding a close inverse relationship was found in the untreated patients between trabecular resorption surfaces (RS%) and calcium Balance. Expand
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