Anabolic effect of human growth hormone: management of inherited disorders of catabolic pathways.

@article{Marsden1994AnabolicEO,
  title={Anabolic effect of human growth hormone: management of inherited disorders of catabolic pathways.},
  author={Deborah L Marsden and Bruce A Barshop and Sylvia B Capistrano-Estrada and Michael Rice and Christina Prodanos and D Sartoris and Jon Wolff and Kimberly L. Jones and Sheldon Spector and William L. Nyhan},
  journal={Biochemical medicine and metabolic biology},
  year={1994},
  volume={52 2},
  pages={145-54}
}
The effects of growth hormone treatment and dietary alanine supplementation, individually and in combination, were studied in five patients with organic acidemias. Three patients had propionic acidemia, one had 3-hydroxyisobutyric acidemia, and one had a defect in isoleucine metabolism. Two patients with propionic acidemia had decreased growth hormone secretion in response to provocative stimuli (intravenous L-arginine and oral levodopa or clonidine); the remaining subjects had sufficient… CONTINUE READING

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AcidosisMay be treated byArginine
Two patients with propionic acidemia had decreased growth hormone secretion in response to provocative stimuli ( intravenous L - arginine and oral levodopa or clonidine ) ; the remaining subjects had sufficient growth hormone secretion .
Two patients with propionic acidemia had decreased growth hormone secretion in response to provocative stimuli ( intravenous L - arginine and oral levodopa or clonidine ) ; the remaining subjects had sufficient growth hormone secretion .
One patient with propionic acidemia expired during the time of the study , following a course of recurrent pancreatitis and an episode of acute basal ganglia infarction .
Three patients had propionic acidemia , one had 3-hydroxyisobutyric acidemia , and one had a defect in isoleucine metabolism .
Three patients had propionic acidemia , one had 3-hydroxyisobutyric acidemia , and one had a defect in isoleucine metabolism .
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