Anabolic effect of genistein in osteoblastic MC3T3-E1 cells.

  title={Anabolic effect of genistein in osteoblastic MC3T3-E1 cells.},
  author={Emi Sugimoto and Masayoshi Yamaguchi},
  journal={International journal of molecular medicine},
  volume={5 5},
Genistein is a natural isoflavone found in Leguminosae. The effect of genistein on osteoblastic MC3T3-E1 cells was investigated. Cells were cultured for 48 h in the presence of genistein (10(-7)-10(-5) M). Genistein (10(-6) and 10(-5) M) caused a significant elevation of protein content, alkaline phosphatase activity, and deoxyriboncleic acid (DNA) content in the cells. The effect of genistein (10-5 M) in increasing protein content, alkaline phosphatase activity and DNA content in the cells was… CONTINUE READING
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