An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region

@article{Nakano2012AnUA,
  title={An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region},
  author={Tatsunori Nakano and Gillian M.G. Lau and Grace M L Lau and Masaya Sugiyama and Masashi Mizokami},
  journal={Liver International},
  year={2012},
  volume={32}
}
The hepatitis C virus (HCV) genomic database is expanding rapidly. 
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A new hepatitis C virus genotype identified in patients originating from the Democratic Republic of Congo is reported, and the prototype QC69 virus is shown to be a new lineage distinct from genotypes 1 to 6.
Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt‐/JNK‐PEPCK signalling pathways
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  • Biology, Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2014
Hepatitis C virus (HCV) infection is highly associated with the type 2 diabetes mellitus, but the detailed mechanisms by which the viral proteins are involved in the clinical outcome remain unclear.
Tracing the Spread of Hepatitis C Virus in Turkey: A Phylogenetic Analysis
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It is shown that HCV genotype 1 (subtype1b) is the main genetic variant of HCV in Turkey but did not reveal any Turkish indigenous phylogenetic cluster, and Turkish strains have their closest matches from both Asia and Europe.
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Persistence of hepatitis C virus (HCV) infection and response to antiviral therapy has been shown to be associated with inappropriate levels of cytokines and microRNAs (miRNAs). miRNA levels have
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The development of new models and tools has led to the discovery and clinical development of a large number of new anti­hepatitis C virus (HCV) drugs, and cure rates have increased to more than 90 percent.
Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource
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This study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near‐)complete genome sequences of HCV available on public databases in May 2013.
Discrepancy between Hepatitis C Virus Genotypes and NS4-Based Serotypes: Association with Their Subgenomic Sequences
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The deep sequencing method provides accurate genotyping results and may be useful for analyzing discrepant cases, and Genotyping by genome amplification showed high consistency, while several false reactions were detected by serotyping.
Intra‐host diversity and evolution of hepatitis C virus endemic to Côte d'Ivoire
TLDR
The results indicate a complex HCV evolution in Côte d'Ivoire, similar to the rest of West Africa, and suggest a unique HCV epidemic history in the country.
Hepatitis C virus protease inhibitor-resistance mutations: our experience and review.
TLDR
A population sequence analysis was performed to assess the frequency of DAA-resistance mutations in the sera of HCV genotype 1-infected patients not treated with HCV protease inhibitors, as well as the experience of patients treated with these drugs.
The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus
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It is concluded that the NS3 linker is critical for mediating protein-protein interactions and dynamic control rather than for modulating the enzymatic functions of NS3-4A.
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