An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region

  title={An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region},
  author={Tatsunori Nakano and Gillian M.G. Lau and Grace M L Lau and Masaya Sugiyama and Masashi Mizokami},
  journal={Liver International},
The hepatitis C virus (HCV) genomic database is expanding rapidly. 
Hepatitis C Virus Genotype 7, a New Genotype Originating from Central Africa
A new hepatitis C virus genotype identified in patients originating from the Democratic Republic of Congo is reported, and the prototype QC69 virus is shown to be a new lineage distinct from genotypes 1 to 6.
Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt‐/JNK‐PEPCK signalling pathways
  • Yi-Chen Kuo, I. Chen, Ming-Fu Chang
  • Biology, Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2014
Hepatitis C virus (HCV) infection is highly associated with the type 2 diabetes mellitus, but the detailed mechanisms by which the viral proteins are involved in the clinical outcome remain unclear.
Tracing the Spread of Hepatitis C Virus in Turkey: A Phylogenetic Analysis
It is shown that HCV genotype 1 (subtype1b) is the main genetic variant of HCV in Turkey but did not reveal any Turkish indigenous phylogenetic cluster, and Turkish strains have their closest matches from both Asia and Europe.
Relation between microRNA‐21, transforming growth factor β and response to treatment among chronic hepatitis C patients
Persistence of hepatitis C virus (HCV) infection and response to antiviral therapy has been shown to be associated with inappropriate levels of cytokines and microRNAs (miRNAs). miRNA levels have
Study on HCV direct acting drugs in treatment of chronic hepatitis C
The development of new models and tools has led to the discovery and clinical development of a large number of new anti­hepatitis C virus (HCV) drugs, and cure rates have increased to more than 90 percent.
Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource
This study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near‐)complete genome sequences of HCV available on public databases in May 2013.
Discrepancy between Hepatitis C Virus Genotypes and NS4-Based Serotypes: Association with Their Subgenomic Sequences
The deep sequencing method provides accurate genotyping results and may be useful for analyzing discrepant cases, and Genotyping by genome amplification showed high consistency, while several false reactions were detected by serotyping.
Intra‐host diversity and evolution of hepatitis C virus endemic to Côte d'Ivoire
The results indicate a complex HCV evolution in Côte d'Ivoire, similar to the rest of West Africa, and suggest a unique HCV epidemic history in the country.
Hepatitis C virus protease inhibitor-resistance mutations: our experience and review.
A population sequence analysis was performed to assess the frequency of DAA-resistance mutations in the sera of HCV genotype 1-infected patients not treated with HCV protease inhibitors, as well as the experience of patients treated with these drugs.
The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus
It is concluded that the NS3 linker is critical for mediating protein-protein interactions and dynamic control rather than for modulating the enzymatic functions of NS3-4A.


Full-length genomic sequence of a hepatitis C virus genotype 2c isolate (BEBE1) and the 2c-specific PCR primers
The entire genome of an Italian isolate of hepatitis C virus is sequenced: the first full-length sequence for the genotype 2c, and its characteristics and differential detection of 2c isolates using PCR are reported.
Detection of hepatitis C virus natural recombinant RF1_2k/1b strain among intravenous drug users in Uzbekistan
Aim:  A series of recent studies have indicated the presence of natural intergenotypic recombinant hepatitis C virus (HCV) strains in distinct parts of the world. The majority of the current
New Natural Intergenotypic (2/5) Recombinant of Hepatitis C Virus
Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy.
Full genome sequence of three isolates of hepatitis C virus subtype 4b from Portugal
It is proposed that three different isolates from Portugal are full genome representatives of the HCV subtype 4b, and grouped within genotype 4 but branched separately from the confirmed subtypes a, d, f and k.
Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.
The nucleotide sequence of the Japanese type of hepatitis C virus (HCV-J) genome, consisting of 9413 nucleotides, was determined by analyses of cDNA clones from plasma specimens from Japanese
A new subtype of hepatitis C virus genotype 1: complete genome and phylogenetic relationships of an Equatorial Guinea isolate.
The complete genome sequence of an HCV genotype 1 isolate from Equatorial Guinea is reported, the first complete HCV-1 genome of African origin and it is proposed that this isolate is a representative of a new, distinct variant of HCV subtype 1.
A natural inter‐genotypic (2b/1b) recombinant of hepatitis C virus in the Philippines
The prevalence study and the characterization of hepatitis C virus (HCV) was carried out in the Philippines and the sequence determination of the 5′‐untranslated region (5′‐UTR)‐Core and the NS5B
Nucleotide sequence of hepatitis C virus (type 3b) isolated from a Japanese patient with chronic hepatitis C.
The genomic sequences of many hepatitis C virus isolates have been reported and a variety of virus genotypes have been classified based on homology in the conserved regions, but the amino acid sequences of these five genotypes were highly homologous in the core, NS3 and NS5B regions but the E2/NS1 region and the NS5A region were poorly conserved.
Evidence of intratypic recombination in natural populations of hepatitis C virus.
Three different genomic regions of four HCV strains isolated from Peruvian patients were sequenced in order to investigate the congruence of HCV genotyping for these three genomic regions, revealing that a crossover event had taken place in the NS5B protein.