An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region

@article{Nakano2012AnUA,
  title={An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region},
  author={Tatsunori Nakano and Gillian M.G. Lau and Grace M L Lau and Masaya Sugiyama and Masashi Mizokami},
  journal={Liver International},
  year={2012},
  volume={32}
}
The hepatitis C virus (HCV) genomic database is expanding rapidly. 
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132 Citations
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Methods Citations
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132 Citations

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A new hepatitis C virus genotype identified in patients originating from the Democratic Republic of Congo is reported, and the prototype QC69 virus is shown to be a new lineage distinct from genotypes 1 to 6. Expand
Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt‐/JNK‐PEPCK signalling pathways
  • Yi-Chen Kuo, I. Chen, +5 authors M. Chang
  • Biology, Medicine
  • Liver international : official journal of the International Association for the Study of the Liver
  • 2014
Hepatitis C virus (HCV) infection is highly associated with the type 2 diabetes mellitus, but the detailed mechanisms by which the viral proteins are involved in the clinical outcome remain unclear.
Tracing the Spread of Hepatitis C Virus in Turkey: A Phylogenetic Analysis
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It is shown that HCV genotype 1 (subtype1b) is the main genetic variant of HCV in Turkey but did not reveal any Turkish indigenous phylogenetic cluster, and Turkish strains have their closest matches from both Asia and Europe. Expand
Relation between microRNA‐21, transforming growth factor β and response to treatment among chronic hepatitis C patients
Persistence of hepatitis C virus (HCV) infection and response to antiviral therapy has been shown to be associated with inappropriate levels of cytokines and microRNAs (miRNAs). miRNA levels have… Expand
Study on HCV direct acting drugs in treatment of chronic hepatitis C
Hepatitis C virus (HCV) infection is a serious public health concern that affects 170 million people worldwide for which no vaccine is available. The hepatitis C virus (HCV) is a small, enveloped,… Expand
Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource
TLDR
This study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near‐)complete genome sequences of HCV available on public databases in May 2013. Expand
Discrepancy between Hepatitis C Virus Genotypes and NS4-Based Serotypes: Association with Their Subgenomic Sequences
TLDR
The deep sequencing method provides accurate genotyping results and may be useful for analyzing discrepant cases, and Genotyping by genome amplification showed high consistency, while several false reactions were detected by serotyping. Expand
Intra‐host diversity and evolution of hepatitis C virus endemic to Côte d'Ivoire
TLDR
The results indicate a complex HCV evolution in Côte d'Ivoire, similar to the rest of West Africa, and suggest a unique HCV epidemic history in the country. Expand
The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus
TLDR
It is concluded that the NS3 linker is critical for mediating protein-protein interactions and dynamic control rather than for modulating the enzymatic functions of NS3-4A. Expand
Hepatitis C Virus Genetic Variability and the Presence of NS5B Resistance-Associated Mutations as Natural Polymorphisms in Selected Genotypes Could Affect the Response to NS5B Inhibitors
TLDR
The genetic variability among HCV genotypes, particularly with the presence of polymorphisms at NNI resistance positions, could affect their responsiveness to NS5B inhibitors and help to provide patients with the full efficacy of NNI-containing regimens. Expand
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