An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region

@article{Nakano2012AnUA,
  title={An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region},
  author={Tatsunori Nakano and Gillian M.G. Lau and Grace M L Lau and Masaya Sugiyama and Masashi Mizokami},
  journal={Liver International},
  year={2012},
  volume={32}
}
The hepatitis C virus (HCV) genomic database is expanding rapidly. 
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136 Citations
Highly Influential Citations
8
Background Citations
59
Methods Citations
4

136 Citations

Hepatitis C Virus Genotype 7, a New Genotype Originating from Central Africa
TLDR
A new hepatitis C virus genotype identified in patients originating from the Democratic Republic of Congo is reported, and the prototype QC69 virus is shown to be a new lineage distinct from genotypes 1 to 6.
Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt‐/JNK‐PEPCK signalling pathways
  • Yi-Chen Kuo, I. Chen, Ming-Fu Chang
  • Biology, Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2014
Hepatitis C virus (HCV) infection is highly associated with the type 2 diabetes mellitus, but the detailed mechanisms by which the viral proteins are involved in the clinical outcome remain unclear.
Tracing the Spread of Hepatitis C Virus in Turkey: A Phylogenetic Analysis
TLDR
It is shown that HCV genotype 1 (subtype1b) is the main genetic variant of HCV in Turkey but did not reveal any Turkish indigenous phylogenetic cluster, and Turkish strains have their closest matches from both Asia and Europe.
Relation between microRNA‐21, transforming growth factor β and response to treatment among chronic hepatitis C patients
Persistence of hepatitis C virus (HCV) infection and response to antiviral therapy has been shown to be associated with inappropriate levels of cytokines and microRNAs (miRNAs). miRNA levels have…
Study on HCV direct acting drugs in treatment of chronic hepatitis C
TLDR
The development of new models and tools has led to the discovery and clinical development of a large number of new anti­hepatitis C virus (HCV) drugs, and cure rates have increased to more than 90 percent.
Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource
TLDR
This study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near‐)complete genome sequences of HCV available on public databases in May 2013.
Discrepancy between Hepatitis C Virus Genotypes and NS4-Based Serotypes: Association with Their Subgenomic Sequences
TLDR
The deep sequencing method provides accurate genotyping results and may be useful for analyzing discrepant cases, and Genotyping by genome amplification showed high consistency, while several false reactions were detected by serotyping.
Intra‐host diversity and evolution of hepatitis C virus endemic to Côte d'Ivoire
TLDR
The results indicate a complex HCV evolution in Côte d'Ivoire, similar to the rest of West Africa, and suggest a unique HCV epidemic history in the country.
Hepatitis C virus protease inhibitor-resistance mutations: our experience and review.
TLDR
A population sequence analysis was performed to assess the frequency of DAA-resistance mutations in the sera of HCV genotype 1-infected patients not treated with HCV protease inhibitors, as well as the experience of patients treated with these drugs.
The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus
TLDR
It is concluded that the NS3 linker is critical for mediating protein-protein interactions and dynamic control rather than for modulating the enzymatic functions of NS3-4A.
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References

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TLDR
The entire genome of an Italian isolate of hepatitis C virus is sequenced: the first full-length sequence for the genotype 2c, and its characteristics and differential detection of 2c isolates using PCR are reported.
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TLDR
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TLDR
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