An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity

@article{Stephens2006AnUO,
  title={An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity},
  author={Jacqueline M. Stephens and Antonio Vidal-Puig},
  journal={Current Opinion in Lipidology},
  year={2006},
  volume={17},
  pages={128–131}
}
Purpose of review The aim of this article is to summarize all of the recent studies on pre-B cell colony-enhancing factor visfatin, a ubiquitously expressed secreted protein that has been implicated in obesity and insulin resistance. Although pre-B-cell colony-enhancing factor was discovered over 10 years ago, there are many remaining questions about the regulation and function of this protein. Recent findings Studies in the last decade have revealed the endocrine properties of fat cells. One… Expand
Visfatin/pre-B-cell colony-enhancing factor: A protein with various suggested functions
TLDR
This review summarizes the current knowledge of the various functions of PBEF/visfatin towards involvements in pathophysiology of several diseases. Expand
Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties1
TLDR
It is shown that recombinant visfatin activates human leukocytes and induces cytokine production and in vivo, visFatin induces circulating IL-6 in BALB/c mice and can be considered a new proinflammatory adipocytokine. Expand
Visfatin is upregulated in type-2 diabetic rats and targets renal cells.
TLDR
The results suggest that visfatin is produced by renal cells and has an important paracrine role in the pathogenesis of diabetic nephropathy. Expand
Visfatin as a Novel Mediator Released by Inflamed Human Endothelial Cells
TLDR
It is suggested that the inflamed endothelium can be a source of visfatin, which arises as a local inflammatory mediator and a potential therapeutic target to interfere with vascular inflammation. Expand
Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
TLDR
Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders. Expand
Autocrine effects of visfatin on hepatocyte sensitivity to insulin action.
TLDR
Evidence is provided that visfatin exhibits important autocrine effects on sensitivity of liver cells to insulin action possibly through its effects on NAD biosynthesis. Expand
Visfatin/Nampt: An Adipokine with Cardiovascular Impact
TLDR
Visfatin/Nampt effects on cytokine and chemokine secretion, macrophage survival, leukocyte recruitment by endothelial cells, vascular smooth muscle inflammation and plaque destabilization make of this adipokine an active factor in the development and progression of atherosclerosis. Expand
Editorial: Retinol binding protein 4 and pathogenesis of diabetes.
TLDR
In obesity, the massive increase in fat mass leads to a significant increase in circulation of many adipose tissue secreted factors that may have pathogenic effects, including proinflammatory adipokines including TNF-α, IL-6, leptin, plasminogen activator inhibitor-1, angiotensinogen, and resistin, among many others. Expand
Visfatin, Obesity, and Cancer
TLDR
This book chapter will particularly focus on both intracellular and extracellular visfatin/Nampt’s contribution to cancer pathophysiology as well as on the mechanisms underlying the connection between visFatin/nampt and cancer. Expand
Visfatin/PBEF/Nampt: A New Cardiovascular Target?
TLDR
Growing evidence has since then unveiled that visfatin/PBEF/Nampt may rather be a biomarker of inflammation and endothelial damage, and also a direct regulator of the cardiovascular system that modulates cell proliferation and survival, extracellular matrix, vascular reactivity, and inflammation. Expand
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TLDR
A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated. Expand
Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes.
TLDR
This study suggests that IL-6 might influence glucose tolerance in part by regulation of the novel insulin-mimetic adipocytokine visfatin. Expand
Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats.
TLDR
Results suggest that rosiglitazone and fenofibrate may prevent type 2 diabetes by regulating adipocytokines including visfatin, adiponectin, and TNF-alpha. Expand
Effect of PPAR-α and -γ agonist on the expression of visfatin, adiponectin, and TNF-α in visceral fat of OLETF rats☆
A variety of adipocytokines and peptides secreted from adipocytes have been considered to play a crucial role in obesity, insulin resistance, and type 2 diabetes. Recently, visfatin, a newExpand
Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury.
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TLDR
PBEF is a novel cytokine constitutively expressed by the fetal membranes during pregnancy and increased the expression of IL-6 and IL-8 and may be important in both normal spontaneous labor and infection-induced preterm labor. Expand
Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation.
TLDR
It is demonstrated that PBEF may be required for complete expression of the thrombin-induced inflammatory response and a potentially novel role for PBEf in the regulation of EC Ca(2+)-dependent cytoskeletal rearrangement and endothelial barrier dysfunction is revealed. Expand
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis.
TLDR
PBEF is identified as a novel inflammatory cytokine that plays a requisite role in the delayed neutrophil apoptosis of clinical and experimental sepsis and is also upregulated in neutrophils by IL-1beta and functions as an inhibitor of apoptosis in response to a variety of inflammatory stimuli. Expand
Pre–B-Cell Colony–Enhancing Factor Regulates NAD+-Dependent Protein Deacetylase Activity and Promotes Vascular Smooth Muscle Cell Maturation
TLDR
Findings identify PBEF as a regulator of NAD+-dependent reactions in SMCs, reactions that promote, among other potential processes, the acquisition of a mature SMC phenotype. Expand
Visfatin: gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats.
TLDR
The relative visfatin gene expression is not associated with the metabolic syndrome in WOKW rats, as an animal model for polygenically inherited metabolic syndrome, compared to lean Dark Agouti (DA) rats. Expand
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