An update on therapy of primary central nervous system lymphoma.

  title={An update on therapy of primary central nervous system lymphoma.},
  author={Lisa M DeAngelis and Fabio M. Iwamoto},
  journal={Hematology. American Society of Hematology. Education Program},
The most important advance in primary central nervous system (CNS) lymphoma treatment has been the convincing data that high-dose methotrexate-based chemotherapy regimens improve survival compared to historical controls treated with radiotherapy alone. However, the optimal treatment approach is still unclear and therapy can be associated with long-term neurotoxicity. Current research focuses on maximizing survival while minimizing neurologic sequelae. 

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  • KS Panageas, EB Elkin, LM DeAngelis, L Ben-Porat, LE Abrey
  • 2005

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