An update on the use of helminths to treat Crohn’s and other autoimmunune diseases

  title={An update on the use of helminths to treat Crohn’s and other autoimmunune diseases},
  author={Aditya Reddy and Bernard Fried},
  journal={Parasitology Research},
This review updates our previous one (Reddy and Fried, Parasitol Research 100: 921–927, 2007) on Crohn’s disease and helminths. The review considers the most recent literature on Trichuris suis therapy and Crohn’s and the significant literature on the use of Necator americanus larvae to treat Crohn’s and other autoimmune disorders. The pros and cons of helminth therapy as related to autoimmune disorders are discussed in the review. We also discuss the relationship of the bacterium Campylobacter… 
Helminth Therapy to Treat Crohn’s and Other Autoimmune Diseases
The use of various helminths or their worm products to treat autoimmune diseases: Inflammatory Bowel Disease, Multiple Sclerosis, Rheumatoid Arthritis, Type-1 Diabetes, and Asthma and allergic disorders is considered.
Autoimmune diseases, treatment with Trichuris suis and some other helminths
Promising outcomes currently exist in regards to helminth therapy applied to treat autoimmune diseases such as Crohn’s disease and ulcerative colitis, summarised in this review.
Parasitic Helminths: New Weapons against Immunological Disorders
Antiallergic/anti-inflammatory effects of helminths together along with a study of the effects of Schistosoma mansoni on Th17-dependent experimental arthritis are summarized.
A study on three aspects of Inflammatory Bowel Disease's Triad of Susceptibility: Hormones, Helminths and T regulatory cells, in the Helicobacter hepaticus mouse model for IBD
The research presented here evaluates one aspect from each of the three susceptibility categories (genetics, environment and immune system) utilizing the H. hepaticus mouse model for IBD.
Trichuris suis Ova in Inflammatory Bowel Disease
Some but not all epidemiological studies suggest that helminth infection in childhood protects against development of inflammatory bowel disease (IBD) in later years, and small trials and series have been published showing some positive effects of Trichuris suis ova in ulcerative colitis and Crohn's disease.
Enfermedades Autoinmunes, tratamiento con Trichuris suis y otros helmintos
This review finds out what the evidence of hygiene hypothesis is and its applications in the field of autoimmune diseases, paying especial attention not only in the action mechanisms in which they are based upon but also in the real outcome obtained.
The role of infection in the aetiology of inflammatory bowel disease
An overview of the infections postulated as being relevant to the onset of IBD is given, in addition to reviewing current knowledge regarding other microorganisms that are associated with modifying the risk of developing IBD.
Helminth/Parasite Treatment of Multiple Sclerosis
  • J. Correale
  • Biology, Medicine
    Current Treatment Options in Neurology
  • 2014
It is strongly recommended that live helminth or ova parasites be administered only to individuals participating in strictly monitored, controlled clinical trials, and much remains to be explored before the field can move from experimental animal models to application in clinical practice.
Biological role of excretory-secretory proteins in endemic parasites of Latin America and the Caribbean.
Key information on the function of excretory/secretory proteins from these parasites in their infectivity, pathogeny and diagnosis is discussed and may lead to new approaches for the clinical management and diagnosis of these diseases.
Prerequisites for the pharmaceutical industry to develop and commercialise helminths and helminth-derived product therapy.


The use of Trichuris suis and other helminth therapies to treat Crohn’s disease
This review summarizes what is known about the underlying mechanisms that may account for the observed patterns in humans treated with helminths for CD and highlights the potential therapeutic benefits that may be realized through the clinical use of Trichuris suis and other helmineths for Crohn’s disease.
Will worms really cure Crohn’s disease?
Extension of this concept into the “hygiene hypothesis” may seem increasingly attractive in terms of an explanation for some epidemiological observations in patients with IBD, in particular the north-south gradient for IBD prevalence in both North America and Europe, and the lack of IBD in developing nations.
Trichuris suis therapy in Crohn’s disease
These findings also support the premise that natural exposure to helminths such as T suis affords protection from immunological diseases like Crohn’s disease.
Is there a role for helminths in the therapy of inflammatory bowel disease?
It is proposed that helminths protect the bowel by downregulating inflammatory responses by regulating immune regulatory responses in animal models of colitis and in human IBD.
Why Trichuris suis should prove safe for use in inflammatory bowel diseases.
This work evaluated surgical tissue from patients with Crohn’s disease for the presence of Mycobacterium avium subspecies paratuberculosis DNA by in situ hybridization and nested polymerase chain reaction, and concluded that Trichuris suis should prove Safe for Use in Inflammatory Bowel Diseases.
A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors
If CD patients tolerate hookworm infection, and the practical issues associated with establishing reservoir donors (RDs) are tested.
Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease
This open trial demonstrates that it is safe to administer eggs from the porcine whipworm, Trichuris suis, to patients with CD and UC and demonstrates improvement in the common clinical indices used to describe disease activity.
Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders
It is concluded that the increasing failure of Treg is a consequence of diminished exposure to certain micro-organisms that are “old friends”, because of their continuous presence throughout mammalian evolution.
Helminths as governors of immune-mediated inflammation.
Epidemiological evidence for a differential effect of hookworm species, Ancylostoma duodenale or Necator americanus, on iron status of children.
The species of hookworm being transmitted in a community influences the burden of iron deficiency anaemia in the community, and should be considered in prioritizing and planning programmes for hookworm and anaemia control.