An update on the use of helminths to treat Crohn’s and other autoimmunune diseases

@article{Reddy2008AnUO,
  title={An update on the use of helminths to treat Crohn’s and other autoimmunune diseases},
  author={Aditya Reddy and Bernard Fried},
  journal={Parasitology Research},
  year={2008},
  volume={104},
  pages={217-221}
}
This review updates our previous one (Reddy and Fried, Parasitol Research 100: 921–927, 2007) on Crohn’s disease and helminths. The review considers the most recent literature on Trichuris suis therapy and Crohn’s and the significant literature on the use of Necator americanus larvae to treat Crohn’s and other autoimmune disorders. The pros and cons of helminth therapy as related to autoimmune disorders are discussed in the review. We also discuss the relationship of the bacterium Campylobacter… 
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Helminth Therapy to Treat Crohn’s and Other Autoimmune Diseases
TLDR
The use of various helminths or their worm products to treat autoimmune diseases: Inflammatory Bowel Disease, Multiple Sclerosis, Rheumatoid Arthritis, Type-1 Diabetes, and Asthma and allergic disorders is considered.
Autoimmune diseases, treatment with Trichuris suis and some other helminths
TLDR
Promising outcomes currently exist in regards to helminth therapy applied to treat autoimmune diseases such as Crohn’s disease and ulcerative colitis, summarised in this review.
Parasitic Helminths: New Weapons against Immunological Disorders
TLDR
Antiallergic/anti-inflammatory effects of helminths together along with a study of the effects of Schistosoma mansoni on Th17-dependent experimental arthritis are summarized.
A study on three aspects of Inflammatory Bowel Disease's Triad of Susceptibility: Hormones, Helminths and T regulatory cells, in the Helicobacter hepaticus mouse model for IBD
TLDR
The research presented here evaluates one aspect from each of the three susceptibility categories (genetics, environment and immune system) utilizing the H. hepaticus mouse model for IBD.
Trichuris suis Ova in Inflammatory Bowel Disease
TLDR
Some but not all epidemiological studies suggest that helminth infection in childhood protects against development of inflammatory bowel disease (IBD) in later years, and small trials and series have been published showing some positive effects of Trichuris suis ova in ulcerative colitis and Crohn's disease.
Enfermedades Autoinmunes, tratamiento con Trichuris suis y otros helmintos
TLDR
This review finds out what the evidence of hygiene hypothesis is and its applications in the field of autoimmune diseases, paying especial attention not only in the action mechanisms in which they are based upon but also in the real outcome obtained.
The role of infection in the aetiology of inflammatory bowel disease
TLDR
An overview of the infections postulated as being relevant to the onset of IBD is given, in addition to reviewing current knowledge regarding other microorganisms that are associated with modifying the risk of developing IBD.
Helminth/Parasite Treatment of Multiple Sclerosis
  • J. Correale
  • Biology, Medicine
    Current Treatment Options in Neurology
  • 2014
TLDR
It is strongly recommended that live helminth or ova parasites be administered only to individuals participating in strictly monitored, controlled clinical trials, and much remains to be explored before the field can move from experimental animal models to application in clinical practice.
Biological role of excretory-secretory proteins in endemic parasites of Latin America and the Caribbean.
TLDR
Key information on the function of excretory/secretory proteins from these parasites in their infectivity, pathogeny and diagnosis is discussed and may lead to new approaches for the clinical management and diagnosis of these diseases.
Prerequisites for the pharmaceutical industry to develop and commercialise helminths and helminth-derived product therapy.
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References

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TLDR
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TLDR
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