An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function.

@article{Fone2008AnUO,
  title={An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function.},
  author={Kevin C. F. Fone},
  journal={Neuropharmacology},
  year={2008},
  volume={55 6},
  pages={1015-22}
}
As the 5-hydroxytryptamine(6) (5-HT(6)) receptor is almost exclusively expressed in the CNS, particularly in areas associated with learning and memory, many studies have examined its role in cognitive function in the rodent, as reviewed herein. Most studies, in healthy adult rats, report that 5-HT(6) receptor antagonists enhance retention of spatial learning in the Morris water maze, improve consolidation in autoshaping tasks and reverse natural forgetting in object recognition. Antagonists… CONTINUE READING