An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.

@article{Durlacher2016AnUO,
  title={An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.},
  author={Cameron T Durlacher and Zhi-ling Li and Xiao-Wu Chen and Zhixu He and Shu-Feng Zhou},
  journal={Clinical and experimental pharmacology & physiology},
  year={2016},
  volume={43 6},
  pages={
          585-601
        }
}
Human Aurora kinases, including Aurora kinase A (AURKA), B (AURKB), and C (AURKC), play an essential role in mitotic events such as monitoring of the mitotic checkpoint, creation of bipolar mitotic spindle and alignment of centrosomes on it, also regulating centrosome separation, bio-orientation of chromosomes and cytokinesis. AURKA and AURKB are key… CONTINUE READING