An update on the pathogenesis of the upper airways in aspirin-exacerbated respiratory disease

@article{Choi2014AnUO,
  title={An update on the pathogenesis of the upper airways in aspirin-exacerbated respiratory disease},
  author={Jeong-Hee Choi and Mi-Ae Kim and Hae‐Sim Park},
  journal={Current Opinion in Allergy and Clinical Immunology},
  year={2014},
  volume={14},
  pages={1–6}
}
Purpose of reviewThe key features of aspirin-exacerbated respiratory diseases (AERDs) include chronic, severe asthma and a high prevalence (60–80%) of chronic rhinosinusitis with nasal polyps, all of which are exacerbated by exposure to aspirin and other NSAIDs. Although the pathogenic mechanisms of AERD are not completely understood, repeated instances have shown intense eosinophilic infiltrations of upper and lower airway mucosa, and dysregulation of arachidonate metabolisms. Here, recent… 
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