An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings

@article{Sharpley2014AnUO,
  title={An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings},
  author={Christopher Francis Sharpley and Suresh K. A. Palanisamy and Nicarla S. Glyde and Peter W. Dillingham and Linda L. Agnew},
  journal={Behavioural Brain Research},
  year={2014},
  volume={273},
  pages={89-105}
}
In the three years since the most recent meta-analysis of the association between the serotonin transported promoter polymorphism (5-HTTLPR), stress and the development of depression, another 27 studies have been published on this issue, which is an increase of 50% more studies than were previously reviewed. In addition, previous findings of inconsistency of results across studies argued for further exploration of this relationship. From the 81 studies identified to June 2013, the significant… 
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
TLDR
If an interaction exists in which the S allele of 5-HTTLPR increases risk of depression only in stressed individuals, then it is not broadly generalisable, but must be of modest effect size and only observable in limited situations.
An integrative review of methylation at the serotonin transporter gene and its dialogue with environmental risk factors, psychopathology and 5-HTTLPR
TLDR
Research preliminarily indicates a methylation‐driven increased vulnerability of carriers of the short allele of 5‐HTTLPR to psychiatric disorders when exposed to early stress or soon after exposure to stress.
Suppression mediates the effect of 5-HTTLPR by stress interaction on depression.
TLDR
It is shown that individuals homozygous for the long allele respond to stressful events by reappraising their emotional meaning, which may hamper the harmful effect of stress on mental health.
The role of the serotonin transporter gene, brain structure and family environment in the emergence of depression during adolescence
TLDR
This thesis aims to enhance current understanding of this interaction by considering how two different dimensions of environmental experience (threat versus deprivation) might interact with the serotonin transporter gene during adolescence, while also investigating potential underlying neurobiological mechanisms.
Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older
TLDR
There may be a differential effect of stressors and 5-HTTLPR on depressive symptoms by ethnicity, but further research is needed, particularly when using a haplotype to characterize variation in 5- HTTLPR in population-based sample with a diverse ethnic composition.
5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer
TLDR
The findings in an original study and a meta-analysis do not support the hypothesis of an association between the 5-HTTLPR genotype and depression after cancer.
Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin Transporter Gene Expression: a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants
TLDR
The genetic architecture of the 5-HTTLPR allelic variants reported so far is detailed, with a closer look at the two single nucleotide polymorphisms (SNPs) rs25531 and rs25532 that lies in the VNTR and thus increase genetic variability of the SLC6A4 promoter.
Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms
TLDR
This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms and suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.
Interaction of the 5-HTTLPR and childhood trauma influences memory bias in healthy individuals.
TLDR
The results suggest that the depression-susceptibility genotype of the 5-HTTLPR is associated with depressive information processing styles when occurring in combination with traumatic childhood events.
No Association Between the 5-HTTLPR Polymorphism and Diurnal Preference in Koreans
Objective: Recent studies have extended the study of diurnal preferences to the genetic level. Most studies have focused on clock genes, but some studies have searched for the possibilities of other
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