An update on the genetic architecture of hyperuricemia and gout

@inproceedings{Merriman2015AnUO,
  title={An update on the genetic architecture of hyperuricemia and gout},
  author={Tony Raymond Merriman},
  booktitle={Arthritis research & therapy},
  year={2015}
}
Genome-wide association studies that scan the genome for common genetic variants associated with phenotype have greatly advanced medical knowledge. Hyperuricemia is no exception, with 28 loci identified. However, genetic control of pathways determining gout in the presence of hyperuricemia is still poorly understood. Two important pathways determining hyperuricemia have been confirmed (renal and gut excretion of uric acid with glycolysis now firmly implicated). Major urate loci are SLC2A9 and… CONTINUE READING

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