An update on the biology and physiology of resistin

@article{Adeghate2004AnUO,
  title={An update on the biology and physiology of resistin},
  author={Ernest Adeghate},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={2485-2496}
}
  • E. Adeghate
  • Published 1 October 2004
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
Abstract.Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules α, β and γ in structure and function. Resistin is produced by white and brown adipose tissues but has also has been identified in several other tissues, including the hypothalamus, pituitary and adrenal glands, pancreas, gastrointestinal tract, myocytes, spleen, white blood cells and plasma. The tissue level of resistin is decreased by insulin, cytokines such as tumour necrosis factor… 

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References

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Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-α in adipose tissue

It is demonstrated that the expression of resistin and RELM α are similarly regulated in adipose tissue despite the fact that RELMα is exclusively expressed in the stromal vascular fraction of adipose tissues and not in adipocytes.

Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.

It is found that resistin expression in 3T3-L1 adipocytes was significantly upregulated by high glucose concentrations and was suppressed by insulin, suggesting that these factors affect insulin sensitivity and fat tissue mass in part by altering the expression and eventual secretion of resistin from adipose cells.

Tumor Necrosis Factor α Is a Negative Regulator of Resistin Gene Expression and Secretion in 3T3-L1 Adipocytes

It is suggested that TNFα is a pivotal negative regulator of resistin gene expression, which may have important implications for the pathogenesis of insulin resistance and its link to obesity.

Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes.

Resistin is expressed in pancreatic islets.

Resistin and obesity-associated insulin resistance

Regulation of resistin by gonadal, thyroid hormone, and nutritional status.

The observations indicate that resistin is influenced by gender, gonadal status, thyroid hormones, pregnancy, and pregnancy, which suggests that resistsin could explain the decreased insulin sensitivity during puberty and could be the link between sex steroids and insulin sensitivity.
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