An update on pharmacotherapy for the treatment of fibromyalgia

@article{Calandre2015AnUO,
  title={An update on pharmacotherapy for the treatment of fibromyalgia},
  author={Elena P Calandre and Fernando Rico-Villademoros and Mahmoud Slim},
  journal={Expert Opinion on Pharmacotherapy},
  year={2015},
  volume={16},
  pages={1347 - 1368}
}
Introduction: Fibromyalgia is a syndrome characterized by chronic generalized pain in addition to different symptoms such as fatigue, sleep disturbances, stiffness, cognitive impairment, and psychological distress. Multidisciplinary treatment combining pharmacological and nonpharmacological therapies is advised. Areas covered: Publications describing randomized controlled trials and long-term extension studies evaluating drug treatment for fibromyalgia were searched in PubMed and Scopus and… 

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Milnacipran for the Treatment of Fibromyalgia.

A more holistic approach is needed to treat fibromyalgia effectively and further research, including direct comparison studies, should be conducted to fully evaluate the usefulness of this drug.

Fibromyalgia Pathogenesis and Treatment Options Update

The most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology, will be summarized, and the evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed.

Combination pharmacotherapy for the treatment of fibromyalgia in adults.

A double-blind, randomised controlled trials comparing combinations of two or more drugs to placebo or other comparators for the treatment of fibromyalgia pain found some evidence that combination pharmacotherapy reduced pain compared to monotherapy.

Saffron (Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trial

Saffron and duloxetine demonstrated comparable efficacy in treatment of fibromyalgia symptoms and Hamilton Rating Scale for Depression, Fibromyalgia Impact Questionnaire, and Brief Pain Inventory.

Adding medical cannabis to standard analgesic treatment for fibromyalgia: a prospective observational study.

This observational study shows that adjunctive MCT offers a possible clinical advantage in FM patients, especially in those with sleep dysfunctions, and the clinical improvement inversely correlated with BMI.

Lidocaine in fibromyalgia: A systematic review

This study demonstrates the short-term effectiveness and safety of intravenous lidocaine in FM patients, however, more studies, including long-term follow-up, are still needed.
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Overall, the use of quetiapine (initiated at a low dose and slowly titrated) in fibromyalgia should be limited to patients with comorbid major depression or patients who are currently receiving other treatments and have unresolved and disabling depressive and/or anxiety symptoms.

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