An update on ketamine and its two enantiomers as rapid-acting antidepressants

@article{Zhang2018AnUO,
  title={An update on ketamine and its two enantiomers as rapid-acting antidepressants},
  author={Kai Zhang and Kenji Hashimoto},
  journal={Expert Review of Neurotherapeutics},
  year={2018},
  volume={19},
  pages={83 - 92}
}
ABSTRACT Introduction: Depression is one of the most disabling diseases worldwide. Approximately one-third of depressed patients are treatment-resistant to the currently available antidepressants and there is a significant therapeutic time lag of weeks to months. There is a clear unmet need for rapid-acting and more efficacious treatments. (R,S)-ketamine, an old anesthetic drug, appears now to be going through a renaissance. Areas covered: This paper reviews recent literature describing the… Expand

Paper Mentions

Interventional Clinical Trial
This study will determine the effectiveness and safety of S-Ketamine in depression patients undergoing electroconvulsive therapy.  
ConditionsDepression, Bipolar, Depression, Unipolar, Major Depressive Disorder, (+1 more)
InterventionDrug
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The author reviews the historical overview of the antidepressant actions of enantiomers of ketamine and its major metabolites norketamine and hydroxynorketamines and discusses the other potential rapid‐acting antidepressant candidates to compare them with ketamine. Expand
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TLDR
With the hippocampus being a key target for ketamine's beneficial antidepressant effects, behavioral and neurochemical effects of drugs that act selectively on the hippocampus due to the preferential location of their receptor targets are examined. Expand
Rapid-Acting Antidepressants.
TLDR
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Esketamine for treatment resistant depression
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Both esketamine’s approval for use in TRD and longer-term safety data may position it preferentially above racemic ketamine, although factors such as cost and monitoring requirements may limit its use. Expand
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