An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus.

@article{Rabinovitch1998AnUO,
  title={An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus.},
  author={Alex Rabinovitch},
  journal={Diabetes/metabolism reviews},
  year={1998},
  volume={14 2},
  pages={129-51}
}
Correlation studies between cytokines expressed in islets and autoimmune diabetes development in NOD mice and BB rats have demonstrated that beta-cell destructive insulitis is associated with increased expression of proinflammatory cytokines (IL-1, TNF alpha, and IFN alpha) and type 1 cytokines (IFN gamma, TNF beta, IL-2 and IL-12), whereas non-destructive (benign) insulitis is associated with increased expression of type 2 cytokines (IL-4 and IL-10) and the type 3 cytokine (TGF beta… CONTINUE READING
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