An update on acquired aplastic anemia

  title={An update on acquired aplastic anemia},
  author={E. Solomou},
  journal={Hematology & Transfusion International Journal},
  • E. Solomou
  • Published 2017
  • Medicine
  • Hematology & Transfusion International Journal
Acquired Aplastic anemia is a rare bone marrow failure syndrome, characterised in most of the cases by autoimmune destruction of hematopoietic stem cells in the bone marrow [1]. The activated cytotoxic T cells in aplastic anemia display various abnormalities, leading to INF-g overproduction. This aberrant IFN-g levels lead to Fas-mediated stem cell death, resulting in replacement of the cellular component of the bone marrow by fat. The result of this replacement is pancytopenia in the… Expand

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