An update of genetic basis of PCOS pathogenesis.

@article{Crespo2018AnUO,
  title={An update of genetic basis of PCOS pathogenesis.},
  author={Raiane P Crespo and T{\^a}nia A.S.S. Bachega and Berenice Bilharinho de Mendonca and Larissa Garcia Gomes},
  journal={Archives of endocrinology and metabolism},
  year={2018},
  volume={62 3},
  pages={
          352-361
        }
}
Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder that affects 5-20% of reproductive age women. PCOS clinical symptoms include hirsutism, menstrual dysfunction, infertility, obesity and metabolic syndrome. There is a wide heterogeneity in clinical manifestations and metabolic complications. The pathogenesis of PCOS is not fully elucidated, but four aspects seem to contribute to the syndrome to different degrees: increased ovarian and/or adrenal androgen secretion… Expand
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The historical and recent findings of genetic studies of PCOS, such as familial studies, twin studies, and molecular genetic studies, including the results of recent genome wide associated studies are summarized. Expand
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