An update for Richter syndrome - new directions and developments.

  title={An update for Richter syndrome - new directions and developments.},
  author={Toby A Eyre and Anna Schuh},
  journal={British journal of haematology},
  volume={178 4},
High-grade transformation of chronic lymphocytic leukaemia [Richter syndrome (RS)] is rare and represents a unique and uncommon clinical challenge. Clonally related diffuse large B cell type RS is a chemotherapy-resistant and devastating disease. Patients are typically elderly, immunosuppressed and present with a rapidly deteriorating performance status. Historical outcomes suggest a median overall survival of approximately 8 months. RS remains is an area of high unmet clinical need. The… CONTINUE READING
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