An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance.

@article{Javelle2006AnUT,
  title={An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance.},
  author={Arnaud Javelle and Domenico Lupo and Lei Zheng and Xiaodan Li and Fritz K. Winkler and Mike Merrick},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 51},
  pages={39492-8}
}
Amt proteins constitute a class of ubiquitous integral membrane proteins that mediate movement of ammonium across cell membranes. They are homotrimers, in which each subunit contains a narrow pore through which substrate transport occurs. Two conserved histidine residues in the pore have been proposed to be necessary for ammonia conductance. By analyzing 14 engineered polar and non-polar variants of these histidines, in Escherichia coli AmtB, we show that both histidines are absolutely required… CONTINUE READING

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