An unusual syncytia-inducing human immunodeficiency virus type 1 primary isolate from the central nervous system that is restricted to CXCR4, replicates efficiently in macrophages, and induces neuronal apoptosis

@article{Yi2003AnUS,
  title={An unusual syncytia-inducing human immunodeficiency virus type 1 primary isolate from the central nervous system that is restricted to CXCR4, replicates efficiently in macrophages, and induces neuronal apoptosis},
  author={Yanjie Yi and Wei Chen and Ian S. Frank and Joann R Cutilli and Anjali Singh and Linda D Starr-Spires and Jerrold Sulcove and Dennis L Kolson and Ronald G. Collman},
  journal={Journal of NeuroVirology},
  year={2003},
  volume={9},
  pages={432-441}
}
Macrophage/microglia cells are the principal targets for human immunodeficiency virus type 1 (HIV-1) in the central nervous system (CNS). Prototype HIV-1 isolates from the CNS are macrophage (M)-tropic, non-syncytia-inducing (NSI), and use CCR5 for entry (R5 strains), but whether syncytia-inducing (SI) CXCR4-using X4 strains might play a role in macrophage/microglia infection and neuronal injury is unknown. To explore the range of features among HIV-1 primary isolates from the CNS, the authors… CONTINUE READING