An unusual sex-determination system in South American field mice (Genus Akodon): the role of mutation, selection, and meiotic drive in maintaining XY females.

@article{Hoekstra2001AnUS,
  title={An unusual sex-determination system in South American field mice (Genus Akodon): the role of mutation, selection, and meiotic drive in maintaining XY females.},
  author={Hopi E Hoekstra and Jonathan M. Hoekstra},
  journal={Evolution; international journal of organic evolution},
  year={2001},
  volume={55 1},
  pages={190-7}
}
The mechanism of sex determination in mammals appears highly conserved: the presence of a Y chromosome triggers the male developmental pathway, whereas the absence of a Y chromosome results in a default female phenotype. However, if the Y chromosome fails to initiate the male pathway (referred to as Y*), XY* females can result, as is the case in several species of South American field mice (genus Akodon). The breeding genetics in this system inherently select against the Y* chromosome such that… CONTINUE READING

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