An unusual ring--a opening and other reactions in steroid transformation by the thermophilic fungus Myceliophthora thermophila.

@article{Hunter2009AnUR,
  title={An unusual ring--a opening and other reactions in steroid transformation by the thermophilic fungus Myceliophthora thermophila.},
  author={Alan Christy Hunter and Kieran R Watts and Cinzia Dedi and Howard T Dodd},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2009},
  volume={116 3-5},
  pages={171-7}
}
A series of steroids (progesterone, testosterone acetate, 17beta-acetoxy-5 alpha-androstan-3-one, testosterone and androst-4-en-3,17-dione) have been incubated with the thermophilic ascomycete Myceliophthora thermophila CBS 117.65. A wide range of biocatalytic activity was observed with modification at all four rings of the steroid nucleus and the C-17beta side-chain. This is the first thermophilic fungus to demonstrate the side-chain cleavage of progesterone. A unique fungal transformation was… CONTINUE READING