An unusual presentation of anti‐Hu‐associated paraneoplastic limbic encephalitis

@article{Langer2012AnUP,
  title={An unusual presentation of anti‐Hu‐associated paraneoplastic limbic encephalitis},
  author={Jennifer E. Langer and Marta Lopes and Nathan B. Fountain and Michael R Pranzatelli and Elizabeth A Thiele and Robert S. Rust and Howard P. Goodkin},
  journal={Developmental Medicine \& Child Neurology},
  year={2012},
  volume={54}
}
Paraneoplastic limbic encephalitis is a rare disorder characterized by personality changes, seizures, memory loss, and psychiatric symptoms often associated with antineuronal antibodies. It is well described in the adult literature but is still underreported in the pediatric literature. Symptoms are usually multifocal and subacute in presentation, occurring over days to weeks; however, in rare cases, symptom onset can be more gradual. We report the case of a 9‐year‐old male with anti‐Hu… 
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A detailed neuroimmunologic profile of a child with both relapsing OMS and ANNA-1 paraneoplastic syndromes and neuroblastoma is provided.
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In children, as in adults, Hu-Abs can be a marker of PNS, however, in contrast to adults,Hu-Abs in children are also associated with an aggressive form of autoimmune nonparaneoplastic limbic encephalitis.
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Autoimmune Neurologic Diseases in Children.
  • M. Sweeney
  • Medicine, Psychology
    Seminars in neurology
  • 2018
TLDR
In this review, autoimmune diseases affecting the brain, spinal cord, nerve roots, peripheral nerves, neuromuscular junction, and muscle in children are described.
Diagnostic Value of Structural and Functional Neuroimaging in Autoimmune Epilepsy
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Several common autoantibodies associated with AE and their structure and function changes in neuroimaging were reviewed to provide help for neurologists to achieve the goal of precision medicine.
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