An unusual meningioma variant with glial fibrillary acidic protein expression

  title={An unusual meningioma variant with glial fibrillary acidic protein expression},
  author={Mingde Su and Koji Ono and Ryuichi Tanaka and Hitoshi Takahashi},
  journal={Acta Neuropathologica},
We studied a recurrent meningioma located in the right frontal lobe. The tumor showed high cellularity and the cells had plump, hyalinous cytoplasm. Immunohistochemically, almost all the tumor cells were positive for epithelial membrane antigen and vimentin, and unexpectedly, glial fibrillary acidic protein (GFAP). Ultrastructural investigation revealed abundant 8- to 10-nm filaments in the cytoplasm. Conspicuous interdigitations with numerous desmosomes were present. Frequently, intracellular… CONTINUE READING

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