An unusual mechanism for ligand antagonism.

@article{Torigoe1998AnUM,
  title={An unusual mechanism for ligand antagonism.},
  author={Chikako Torigoe and John K. Inman and Henry Metzger},
  journal={Science},
  year={1998},
  volume={281 5376},
  pages={568-72}
}
The ratio of late to early events stimulated by the mast cell receptor for immunoglobulin E (IgE) correlated with the affinity of a ligand for the receptor-bound IgE. Because excess receptors clustered by a weakly binding ligand could hoard a critical initiating kinase, they prevented the outnumbered clusters engendered by the high-affinity ligands from launching the more complete cascade. A similar mechanism could explain the antagonistic action of some peptides on the activation of T cells. 
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