An unusual explanation for low oxygen saturation.

@article{Holbrook2008AnUE,
  title={An unusual explanation for low oxygen saturation.},
  author={Simon P. Holbrook and Audrey Quinn},
  journal={British journal of anaesthesia},
  year={2008},
  volume={101 3},
  pages={
          350-3
        }
}
Pulse oximeters are now commonplace in modern medical practice, but we still need to be aware of their limitations. We present here a case of a 62-yr-old gentleman who underwent general anaesthesia for a recurrent parietal meningioma. He had received multiple general anaesthetics in the past. Persistent low pulse oximetry readings in the perioperative period, without any suggestion of respiratory compromise, led us to investigate him further and to discover a new, but benign, haemoglobinopathy. 
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  • 2009
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References

SHOWING 1-10 OF 18 REFERENCES
Hemoglobinopathy case finding by pulse oximetry
TLDR
This case reiterates the limitations of pulse oximetry in patients with dyshemoglobinemias, while introducing its use as a case‐finding tool for such conditions.
Haemoglobin Hammersmith precludes monitoring with conventional pulse oximetry
TLDR
Conventional dual wavelength puke oximeters cannot give an accurate estimate of oxygenation in patients with haemoglobin Hammersmith and assessment of oxygenations in these patients requires alternative monitoring techniques.
The anesthetic management of a patient with hemoglobin MIwate
TLDR
A patient with hemoglobin M(Iwate), a rare inheritable hemoglobinopathy rendering pulse oximetry completely useless because of its anomalous absorption spectrum is treated.
Non-invasive Monitoring of ICP in Infants
TLDR
The aim of this study was to define normal values of AFP with the RTT by means of a special skull adaptor to avoid the fact that externally exerted pressure may interfere with the actual recording of ICP.
Low pulse oximeter‐measured hemoglobin oxygen saturations with hemoglobin Cheverly
TLDR
Hemoglobin Cheverly is an unstable hemoglobin that has a similar mutation as the β‐42 Phe→Ser mutation seen in hemoglobin Hammersmith, and low pulse‐oximeter oxygenation determinations for these hemoglobins do not appear to predict clinical hypoxemia.
Pulse oximetry and genetic hemoglobinopathies
TLDR
Low SpO2 values in asymptomatic patients without cyanosis raise suspicion of a genetic hemoglobinopathy, and a β-globin chain variant named hemoglobin Hammersmith is identified, leading to a severe hemolytic anemia.
Screening and genetic diagnosis of haemoglobinopathies
  • J. Old
  • Medicine, Biology
    Scandinavian journal of clinical and laboratory investigation
  • 2007
TLDR
Although haemoglobinopathy mutations are rarely found in individuals of North European origin, the number of immigrants in the North European countries is steadily increasing and the variety of their ethnic origins poses a problem for screening and accurate diagnosis.
Available from http://www.oxfordradcliffe.nhs.uk/forpatients/departments/ labs/haemoglobinopathy/haemoglobinopathy.aspx
  • Available from http://www.oxfordradcliffe.nhs.uk/forpatients/departments/ labs/haemoglobinopathy/haemoglobinopathy.aspx
  • 2008
History of oxygen saturation monitoring
  • Moyle TB, ed. Pulse Oximetry, 2nd Edn. London: BMJ Books,
  • 2002
Limitations and morbidity
  • Moyle JTB, ed. Pulse Oximetry, 2nd Edn. London: BMJ Books,
  • 2002
...
1
2
...