An unusual RNA tertiary interaction has a role for the specific aminoacylation of a transfer RNA.

@article{Hou1993AnUR,
  title={An unusual RNA tertiary interaction has a role for the specific aminoacylation of a transfer RNA.},
  author={Y. M. Hou and Eric Westhof and Richard Gieg{\'e}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 14},
  pages={6776-80}
}
The nucleotides in a tRNA that specifically interact with the cognate aminoacyl-tRNA synthetase have been found largely located in the helical stems, the anticodon, or the discriminator base, where they vary from one tRNA to another. The conserved and semiconserved nucleotides that are responsible for the tRNA tertiary structure have been shown to have little role in synthetase recognition. Here we report that aminoacylation of Escherichia coli tRNA(Cys) depends on the anticodon, the… CONTINUE READING
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