An unpaired mouse centromere passes consistently through male meiosis and does not significantly compromise spermatogenesis

@article{Mee2003AnUM,
  title={An unpaired mouse centromere passes consistently through male meiosis and does not significantly compromise spermatogenesis},
  author={Patrick J. Mee and Ming Hong Shen and Austin G. Smith and William R. A. Brown},
  journal={Chromosoma},
  year={2003},
  volume={112},
  pages={183-189}
}
ST1 is an artificial mini-chromosome approximately 4.5 Mb in size containing mouse minor and major satellite DNA, human alphoid DNA and sequences derived from interval 5 of the human Y chromosome. Here we have measured the mitotic and meiotic transmission of ST1 and have used the mini-chromosome to define the ability of mice to monitor the presence of unpaired centromeres during meiosis. ST1 is mitotically stable, remaining intact and autonomous in mice for many generations. Female mice… CONTINUE READING