An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis

@article{Kaur2014AnUA,
  title={An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis},
  author={S. Kaur and A. Fielding and Gisela Gassner and N. J. Carter and S. J. Royle},
  journal={eLife},
  year={2014},
  volume={3}
}
Clathrin-mediated endocytosis (CME) is the major internalisation route for many different receptor types in mammalian cells. CME is shut down during early mitosis, but the mechanism of this inhibition is unclear. In this study, we show that the mitotic shutdown is due to an unmet requirement for actin in CME. In mitotic cells, membrane tension is increased and this invokes a requirement for the actin cytoskeleton to assist the CME machinery to overcome the increased load. However, the actin… Expand

Topics from this paper

ERM proteins: The missing actin linkers in clathrin-mediated endocytosis
Hot-wiring clathrin-mediated endocytosis in human cells
Clathrin heavy chain phosphorylated at T606 plays a role in proper cell division
Frustrated clathrin-mediated endocytosis – causes and possible functions
Cell spreading area regulates clathrin-coated pit dynamics on micropatterned substrate.
Local actin polymerization during endocytic carrier formation.
Endosomal Trafficking During Mitosis and Notch-Dependent Asymmetric Division.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Clathrin-mediated endocytosis is inhibited during mitosis
Mitotic inhibition of clathrin-mediated endocytosis
Clathrin-mediated endocytosis persists during unperturbed mitosis.
Mitotic cytosol inhibits invagination of coated pits in broken mitotic cells
Negative Regulation of the Endocytic Adaptor Disabled-2 (Dab2) in Mitosis*
Functions of actin in endocytosis
Endocytosis Resumes during Late Mitosis and Is Required for Cytokinesis*
Actin dynamics counteract membrane tension during clathrin-mediated endocytosis
Clathrin is required for the function of the mitotic spindle
Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis
...
1
2
3
4
5
...