An unknown genetic defect increases venous thrombosis risk, through interaction with protein C deficiency.

@article{Hasstedt1998AnUG,
  title={An unknown genetic defect increases venous thrombosis risk, through interaction with protein C deficiency.},
  author={Sandra J Hasstedt and Edwin G. Bovill and Peter W. Callas and George L. Long},
  journal={American journal of human genetics},
  year={1998},
  volume={63 2},
  pages={569-76}
}
We used two-locus segregation analysis to test whether an unknown genetic defect interacts with protein C deficiency to increase susceptibility to venous thromboembolic disease in a single large pedigree. Sixty-seven pedigree members carry a His107Pro mutation in the protein C gene, which reduces protein C levels to a mean of 46% of normal. Twenty-one… CONTINUE READING