An unexpected tandem cycloaddition reaction of α,β-unsaturated acid chloride with amines: Synthesis of dihydropyrancarboxamide derivatives and biological activity

@article{Elassar2015AnUT,
  title={An unexpected tandem cycloaddition reaction of $\alpha$,$\beta$-unsaturated acid chloride with amines: Synthesis of dihydropyrancarboxamide derivatives and biological activity},
  author={Abdel-Zaher A. Elassar},
  journal={European Journal of Chemistry},
  year={2015},
  volume={6},
  pages={387-393}
}
Tandem cycloaddition reaction of α,β-unsaturated acid chloride with amines afforded in situ N -acylated amines, which undergoes cycloaddition reaction with other molecule of acid chloride to give dihydropyran carboxamide derivatives as an unexpected product. 2-Amino benzimidazole, 2-aminobenzthiazole, 2-aminothiazole, anthranilic acid, o -pheneylenediamine, and 3-methyl-1 H- pyrazol-5(4 H )-one are reacted with methacryloyl chloride at 0 °C to give different derivatives of dihydropyran… Expand

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Tandem Organic Reactions
Aldol Condensation. Michael Reactions. Tandem Vicinal Difunctionalization of Alkenes and Alkynes. Dieckmann and Claisen Cyclizations. Mannich Reaction. Diels-Alder Reactions. Other Cycloadditions.Expand
Dihydropyran derivatives
A number of 2-(hydroxyalkoxy)-3,4-dihydropyrans were synthesized by diene condensation of monovinyl ethers of glycols with acrolein, and some of their chemical transformations were studied. They wereExpand