An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch

@inproceedings{Sun2013AnUR,
  title={An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch},
  author={Chicheng Sun and Lei Zhang and Gong Chen},
  booktitle={Molecular Brain},
  year={2013}
}
GABAA receptors are ligand-gated Cl- channels, and the intracellular Cl- concentration governs whether GABA function is excitatory or inhibitory. During early brain development, GABA undergoes functional switch from excitation to inhibition: GABA depolarizes immature neurons but hyperpolarizes mature neurons due to a developmental decrease of intracellular Cl- concentration. This GABA functional switch is mainly mediated by the up-regulation of KCC2, a potassium-chloride cotransporter that… CONTINUE READING
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