An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.

@article{Pang2009AnUR,
  title={An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.},
  author={Daniel S J Pang and Christian J Robledo and David R Carr and Thomas C Gent and Alexei L Vyssotski and Alex Caley and Anna Y. Zecharia and William Wisden and Stephen G Brickley and Nicholas P Franks},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 41},
  pages={17546-51}
}
TASK channels are acid-sensitive and anesthetic-activated members of the family of two-pore-domain potassium channels. We have made the surprising discovery that the genetic ablation of TASK-3 channels eliminates a specific type of theta oscillation in the cortical electroencephalogram (EEG) resembling type II theta (4-9 Hz), which is thought to be important in processing sensory stimuli before initiating motor activity. In contrast, ablation of TASK-1 channels has no effect on theta… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 9 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 51 references

A Practical Guide to Wavelet Analysis

Christopher Torrence, Gilbert P. Compo
1998
View 3 Excerpts
Highly Influenced

Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 1 Excerpt

Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: Molecular cloning of an anestheticactivated potassium channel from Lymnaea stagnalis

I Andres-Enguix
J Biol Chem 282:20977–20990 • 2007
View 1 Excerpt

TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…