An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses.

Abstract

The ovalbumin(323-339) peptide that binds H2I-A(b) was engineered into the globular heads of hemagglutinin (H) molecules from serologically non-cross-reactive H1N1 and H3N2 influenza A viruses, the aim being to analyze recall CD4+ T cell responses in a virus-induced respiratory disease. Prime/challenge experiments with these H1ova and H3ova viruses in H2(b… (More)

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@article{Thomas2006AnUA, title={An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses.}, author={Paul G Thomas and Scott Anthony Brown and Wen Yue and Jenny M P So and Richard Webby and Peter C. Doherty}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2006}, volume={103 8}, pages={2764-9} }