An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes

@article{Cassell1999AnUP,
  title={An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes},
  author={Paul G. Cassell and Maria Neverova and Salima Janmohamed and Nnanna C Uwakwe and Asiya Abdus Salam Qureshi and Mark I. McCarthy and Philip John Saker and Lorraine Albon and Peter G. Kopelman and Kate Noonan and Juliet L. Easlick and Ambady Ramachandran and Chamukuttan Snehalatha and Claire Pecqueur and Daniel Ricquier and Charles David Warden and Graham A. Hitman},
  journal={Diabetologia},
  year={1999},
  volume={42},
  pages={688-692}
}
Aims/hypothesis. Linkage between markers close to the uncoupling protein 2 and 3 genes (11q13) and resting metabolic rate and a pre-diabetic phenotype have been found. The syntenic region in mouse has been found to be linked to quantitative traits associated with obesity and diabetes. UCP2 and UCP3 could therefore have an important role in body weight regulation and susceptibility to diabetes. We investigated a recently identified variant of the UCP2 gene in exon 8 as a marker for glucose and… CONTINUE READING
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