An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation

@inproceedings{Matsuo2016AnUI,
  title={An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation},
  author={Yuzy Matsuo and Sebastian P Maurer and Masashi Yukawa and Silva Zakian and Martin R Singleton and Thomas Surrey and Takashi Toda},
  booktitle={Journal of cell science},
  year={2016}
}
Dynamic microtubule plus-ends interact with various intracellular target regions such as the cell cortex and the kinetochore. Two conserved families of microtubule plus-end-tracking proteins, the XMAP215, ch-TOG or CKAP5 family and the end-binding 1 (EB1, also known as MAPRE1) family, play pivotal roles in regulating microtubule dynamics. Here, we study the functional interplay between fission yeast Dis1, a member of the XMAP215/TOG family, and Mal3, an EB1 protein. Using an in vitro microscopy… CONTINUE READING
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