An unconventional KITENIN/ErbB4-mediated downstream signal of EGF upregulates c-Jun and the invasiveness of colorectal cancer cells.

@article{Bae2014AnUK,
  title={An unconventional KITENIN/ErbB4-mediated downstream signal of EGF upregulates c-Jun and the invasiveness of colorectal cancer cells.},
  author={Jeong A Bae and Somy Yoon and So-Yeon Park and Jae Hyuk Lee and Jun Eul Hwang and Hangun Kim and Young-Woo Seo and Yoon Jin Cha and Sung Pil Hong and H Y Kim and Ik Joo Chung and Kyung Keun Kim},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2014},
  volume={20 15},
  pages={4115-28}
}
PURPOSE EGF-stimulated signaling via EGF receptor (EGFR) is important in colorectal tumorigenesis and drug targeting. However, anti-EGFR therapy is not effective in a subset of patients with colorectal cancer, suggesting that unidentified EGF-stimulated pathways might play roles in colorectal cancer. Previously, we identified KAI1 C-terminal interacting tetraspanin (KITENIN) as a metastasis-enhancing gene and found it to be highly expressed in sporadic colorectal cancer tissues. We recently… CONTINUE READING