An unbiased metric of antiproliferative drug effect in vitro

Abstract

In vitro cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery. Using theoretical modeling and experimentation, we show that current metrics of antiproliferative small molecule effect suffer from time-dependent bias, leading to inaccurate assessments of parameters such as drug potency and efficacy. We propose the… (More)
DOI: 10.1038/nmeth.3852

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