An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth

@article{Drake2012AnUM,
  title={An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth},
  author={Amanda Jane Drake and Rhoanne C. McPherson and Keith M. Godfrey and Cyrus Cooper and Karen A Lillycrop and Mark A. Hanson and Richard R. Meehan and Jonathan R Seckl and Rebecca M. Reynolds},
  journal={Clinical Endocrinology},
  year={2012},
  volume={77}
}
In epidemiological studies, adverse early‐life conditions associate with subsequent cardiometabolic disease. Hypothesized causes include maternal malnutrition, foetal glucocorticoid overexposure and reduced growth factors. Animal studies suggest a role for epigenetic processes in maintaining early‐life effects into adulthood, but human relevance is unknown. We aimed to investigate relationships between an unbalanced maternal diet in pregnancy, neonatal and adult anthropometric variables with… 

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...

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