An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth

  title={An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth},
  author={Amanda Jane Drake and Rhoanne C. McPherson and Keith M. Godfrey and Cyrus Cooper and Karen A Lillycrop and Mark A. Hanson and Richard R. Meehan and Jonathan R Seckl and Rebecca M. Reynolds},
  journal={Clinical Endocrinology},
In epidemiological studies, adverse early‐life conditions associate with subsequent cardiometabolic disease. Hypothesized causes include maternal malnutrition, foetal glucocorticoid overexposure and reduced growth factors. Animal studies suggest a role for epigenetic processes in maintaining early‐life effects into adulthood, but human relevance is unknown. We aimed to investigate relationships between an unbalanced maternal diet in pregnancy, neonatal and adult anthropometric variables with… 

Maternal Nutrition and Epigenetics in Early Life

Recent human studies that investigated associations between epigenetic marks in the offspring and maternal nutritional status are reviewed, from extreme caloric restriction and nutrients deficiency during pregnancy to maternal obesity and gestational diabetes.

Effect of Maternal and Paternal Nutrition on DNA Methylation in the Offspring: A Systematic Review of Human and Animal Studies

This is a systematic review of studies in humans and animals specifically investigating DNA methylation in progeny in relation to diet of the mother or father, or previous generations, and the types of diet studied.

Nutrition in Early Life, Epigenetics, and Health

The existing human and animal evidence which supports the interaction between nutrition and epigenetics in early life and its lasting impacts on health and development are introduced.

Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood

To better understand the role of maternal health and nutrition in the initiation and progression of diseases in childhood and adulthood, it is necessary to identify the physiological and/or pathological roles of specific nutrients on the epigenome and how dietary interventions in utero and early life could modulate disease risk through epigenomic alteration.

The Impact of Nutritional Interventions in Pregnant Women on DNA Methylation Patterns of the Offspring: A Systematic Review

The results of the included trials are consistent with micronutrient supplementation not significantly affecting offspring tissue DNA methylation patterns, yet subgrouping by sex, BMI, and smoking status increased the significance of nutritional supplementation onDNA methylation.

Glucocorticoids and Fetal Programming; Necessary and Sufficient?

Epidemiological evidence suggests that early life adversity, as marked by lower birth weight, associates with a substantially increased risk of cardiometabolic and neuropsychiatric disorders in later

Adverse maternal exposures, methylation of glucocorticoid-related genes and perinatal outcomes: a systematic review.

NR3C1 and HSD11 β methylation are useful biomarkers of specific environmental stressors associated with important perinatal outcomes that determine pediatric and adult disease risk.

Role of maternal nutrition in programming adiposity in the offspring: potential implications of glucocorticoids

  • C. Breton
  • Biology, Medicine
    Hormone molecular biology and clinical investigation
  • 2013
The inappropriate glucocorticoid levels and modified tissue sensitivity might be key actors of perinatal programming and long-lasting altered adipose tissue activity in the offspring.



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Epigenetic epidemiology of the developmental origins hypothesis.

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Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

The results indicate that stress experience early in pregnancy may contribute to male neurodevelopmental disorders through impacts on placental function and fetal development.

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Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus.

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Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction

Insight is given into the potential contribution of epigenomic dysregulation in mediating the long-term consequences of IUGR, and the value of this approach to studies of the fetal origin of adult disease is demonstrated.

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

Prenatal exposure to increased third trimester maternal depressed/anxious mood was associated with increased methylation of NR3C1 at a predicted NGFI-A binding site, which may offer a potential epigenetic process that links antenatal maternal mood and altered HPA stress reactivity during infancy.

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity

The findings suggest a substantial component of metabolic disease risk has a prenatal developmental basis and perinatal epigenetic analysis may have utility in identifying individual vulnerability to later obesity and metabolic disease.

Stress responsiveness in adult life: influence of mother's diet in late pregnancy.

These findings provide the first human evidence that an unbalanced high protein maternal diet during late pregnancy leads to increased cortisol secretion in response to psychological stress in the offspring.