An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.


People with pale skin, red hair, freckles and an inability to tan--the 'red hair/fair skin' phenotype--are at highest risk of developing melanoma, compared to all other pigmentation types. Genetically, this phenotype is frequently the product of inactivating polymorphisms in the melanocortin 1 receptor (MC1R) gene. MC1R encodes a cyclic AMP-stimulating G… (More)
DOI: 10.1038/nature11624


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