An ultrastructural morphometric analysis of elastase-treated hamster bronchi shows discharge followed by progressive accumulation of secretory granules.

@article{Breuer1987AnUM,
  title={An ultrastructural morphometric analysis of elastase-treated hamster bronchi shows discharge followed by progressive accumulation of secretory granules.},
  author={Raphael Breuer and Thomas G. Christensen and Edgar C. Lucey and Phillip J. Stone and Gordon L. Snider},
  journal={The American review of respiratory disease},
  year={1987},
  volume={136 3},
  pages={698-703}
}
An ultrastructural morphometric analysis of bronchial secretory cells was carried out on hamsters treated intratracheally with 300 micrograms of human neutrophil elastase (HNE) in 0.5 ml saline, saline alone, or left untreated. Five to 6 animals were killed at 2 h and at 3, 8, and 16 days after treatment. Electron micrographs were prepared from the hilar region of the left main intrapulmonary airway; 125 +/- 16 (mean +/- SE) granulated secretory cells extending from basement membrane to lumen… CONTINUE READING