An ultrasensitive homogeneous chemiluminescent assay for microRNAs.

Abstract

On the basis of a dual-amplification strategy, microRNA (miRNA) hybridization amplification by a duplex-specific nuclease (DSN) and signal amplification by a DNAzyme, a highly sensitive and selective homogeneous miRNA assay is developed. By leveraging on the cumulative and selective nature of the DSN amplification process, excellent sensitivity and selectivity are accomplished.

DOI: 10.1039/c3cc44824j

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Cite this paper

@article{Deng2013AnUH, title={An ultrasensitive homogeneous chemiluminescent assay for microRNAs.}, author={Huimin Deng and Yuqian Ren and Wei Shen and Zhiqiang Gao}, journal={Chemical communications}, year={2013}, volume={49 82}, pages={9401-3} }