An ultrasensitive bacterial motor revealed by monitoring signaling proteins in single cells.

@article{Cluzel2000AnUB,
  title={An ultrasensitive bacterial motor revealed by monitoring signaling proteins in single cells.},
  author={Philippe Cluzel and Michael G. Surette and Stanislas Leibler},
  journal={Science},
  year={2000},
  volume={287 5458},
  pages={
          1652-5
        }
}
Understanding biology at the single-cell level requires simultaneous measurements of biochemical parameters and behavioral characteristics in individual cells. [...] Key Method The concentration of this molecule, fused to green fluorescent protein, was monitored with fluorescence correlation spectroscopy. Motors from different bacteria exhibited an identical steep input-output relation, suggesting that they actively contribute to signal amplification in chemotaxis. This experimental approach can be extended to…Expand
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